Reversal of sodium arsenite inhibition of rat liver microsomal Ca2+ pumping ATPase by vitamin C.

نویسندگان

  • O O Odunuga
  • G W Okunade
  • O O Olorunsogo
چکیده

Sodium arsenite (NaAsO2), at 10% of its median lethal dose, was administered to rats with and without vitamin C pretreatment. Liver microsomal fraction was isolated and the activity of Ca2+-ATPase was assayed. Sodium arsenite was found to inhibit the activity of the liver microsomal Ca2+-ATPase to 50% to that of control rats. The specific activity of the enzyme in rats administered sodium arsenite with vitamin C pretreatment was not significantly different from that of control rats.

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عنوان ژورنال:
  • Bioscience reports

دوره 19 1  شماره 

صفحات  -

تاریخ انتشار 1999